Having a bigger waistline and a high body mass index (BMI) in your 60s is not so great. It may be linked with greater signs of brain aging years later. The study published in the July 24, 2019, online issue of Neurology, suggests that these factors may accelerate brain aging by at least a decade.
“People with bigger waists and higher BMI were more likely to have thinning in the cortex area of the brain, which implies that obesity is associated with reduced gray matter of the brain,” said study author Tatjana Rundek, MD, PhD, of University of Miami Miller School of Medicine and a member of the American Academy of Neurology. “These associations were especially strong in those who were younger than 65, which adds weight to the theory that having poor health indicators in mid-life may increase the risk for brain aging and problems with memory and thinking skills in later life.”
The study involved 1,289 people with an average age of 64. Two-thirds of the participants were Latino. At the beginning of the study, Participants had their BMI and waist circumference measured. An average of six years later, participants had MRI brain scans to measure the thickness of the cortex area of the brain, overall brain volume and other factors.
BMI and Waist Circumference
In the normal weight range, a total of 346 of the participants had a BMI of less than 25. There were 372 people, considered overweight, who had a BMI of 30 or over. Finally, 372 people considered obese, had a BMI of 30 or higher.
Waist circumference, can be different for men and women. In the study, the normal weight group, which was 54 percent women, had an average of 33 inches. The overweight group, which was 56 percent women, had an average of 36 inches. Lastly, the obese group, which was 73 percent women, had an average of 41 inches.
Having a higher BMI was associated with having a thinner cortex. This proved true even after researchers adjusted for other factors that could affect the cortex. These other factors included high blood pressure, alcohol use and smoking. In overweight people, every unit increase in BMI connected with a 0.098 millimeter (mm) thinner cortex. In obese people with a 0.207 mm thinner cortex. Having a thinner cortex seems to reflect an increased risk of Alzheimer’s disease.
Besides having a higher BMI, carrying extra weight around the waist also linked to a thinner cortex. Again, this connection proved true even after researchers adjusted for other factors.
Rundek said, “In normal aging adults, the overall thinning rate of the cortical mantle is between 0.01 and 0.10 mm per decade, and our results would indicate that being overweight or obese may accelerate aging in the brain by at least a decade.”
What Losing Weight Means for the Brain
“These results are exciting because they raise the possibility that by losing weight, people may be able to stave off aging of their brains and potentially the memory and thinking problems that can come along with brain aging,” Rundek said. “However, with the rising number of people globally who are overweight or obese and the difficulty many experience with losing weight, obviously this is a concern for public health in the future as these people age.”
Rundek noted that the study does not prove that extra weight causes the cortex to get thinner; it only shows an association.
A limitation of the study was that, like many studies of older people, it is possible that the healthiest people are more likely to live longer and take part in studies, so that may affect the results.
Funding: The National Institute of Neurological Disorders and Stroke and the Evelyn F. McKnight Brain Institute supported this study.